When it comes to fashion, facial tissue is nothing to sneeze at anymore. Kleenex has enlisted designer Isaac Mizrahi for a new marketing campaign and collection of tissue boxes, as the brand already known for novel oval and fruit-inspired wedge boxes looks to take its design to the next level.

A design-focused campaign kicks off with a TV ad from JWT, New York, breaking Jan. 6 showing Kleenex boxes as part of colorful home designs as the Kimberly-Clark Corp. brand looks to burnish its credentials as a trendsetter in home dcor.

Mr. Mizrahi will contribute to the style-focused Style Studio microsite for Kleenex, which is wrapped up with the celebration of the brand’s 90th anniversary. The site, among other things, points out that Kleenex boxes have twice been featured in New York’s Metropolitan Museum of Art.